Enum: SourceMaterialTypeEnum
Permissible Values
| Value | Meaning | Description |
|---|---|---|
| ADDITIONAL_METASTATIC | None | A metastatic tumor sample collected in addition to a previously collected met... |
| ADDITIONAL_NEW_PRIMARY | None | A new primary tumor sample collected in addition to a previously collected pr... |
| BENIGN_NEOPLASMS | None | Tissue derived from a non-cancerous tumor that does not invade nearby tissue ... |
| BLOOD_DERIVED_CANCER_BONE_MARROW | None | Cancerous cells isolated from bone marrow as part of a blood-derived cancer s... |
| BLOOD_DERIVED_CANCER_BONE_MARROW_POST_TREATMENT | None | Cancerous cells isolated from bone marrow following therapeutic intervention |
| BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD | None | Cancerous cells isolated from peripheral blood as part of a blood-derived can... |
| BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD_POST_TREATMENT | None | Cancerous cells isolated from peripheral blood following therapeutic interven... |
| BLOOD_DERIVED_LIQUID_BIOPSY | None | Tumor-derived material, such as circulating tumor DNA or cells, extracted fro... |
| BLOOD_DERIVED_NORMAL | None | Non-cancerous blood sample used as a normal reference for genomic or molecula... |
| BONE_MARROW_NORMAL | None | Non-cancerous bone marrow sample used as a normal reference for genomic or mo... |
| BUCCAL_CELL_NORMAL | None | Normal cells collected from the inner cheek mucosa, typically used as a germl... |
| CELL_LINE_DERIVED_XENOGRAFT_TISSUE | None | Tumor tissue derived from a xenograft model that was originally established f... |
| CELL_LINES | None | Immortalized cells grown in culture, derived from tumor or normal tissue for ... |
| CONTROL_ANALYTE | None | A reference material used to validate or calibrate laboratory assays and anal... |
| DNA | None | Deoxyribonucleic acid extracted from a biological sample for genomic analysis |
| EBV_IMMORTALIZED_NORMAL | None | Normal B-lymphocytes immortalized by Epstein-Barr virus transformation, used ... |
| EXPANDED_NEXT_GENERATION_CANCER_MODEL | None | A cancer model, such as an organoid or cell line, that has been propagated or... |
| FFPE_RECURRENT | None | Formalin-fixed paraffin-embedded tissue from a recurrent tumor, preserved for... |
| FFPE_SCROLLS | None | Thin sections cut from formalin-fixed paraffin-embedded tissue blocks for nuc... |
| FIBROBLASTS_FROM_BONE_MARROW_NORMAL | None | Normal fibroblast cells isolated from bone marrow, used as a non-cancerous re... |
| GRANULOCYTES | None | White blood cells of the granulocyte lineage isolated from blood, often used ... |
| HUMAN_TUMOR_ORIGINAL_CELLS | None | Primary tumor cells taken directly from a human subject without prior in vitr... |
| IN_SITU_NEOPLASMS | None | Tissue from a neoplasm that has not yet invaded surrounding tissue, represent... |
| LYMPHOID_NORMAL | None | Non-cancerous lymphoid tissue used as a normal reference for genomic or molec... |
| METASTATIC | None | Tumor tissue collected from a site distant from the primary tumor, representi... |
| MIXED_ADHERENT_SUSPENSION | None | A cell culture sample containing both adherent and suspension cell population... |
| MONONUCLEAR_CELLS_FROM_BONE_MARROW_NORMAL | None | Normal mononuclear cells isolated from bone marrow, used as a non-cancerous r... |
| NEOPLASMS_OF_UNCERTAIN_AND_UNKNOWN_BEHAVIOR | None | Tissue from a neoplasm whose malignant potential cannot be determined based o... |
| NEXT_GENERATION_CANCER_MODEL | None | A modern in vitro or in vivo cancer model, such as a patient-derived organoid... |
| NORMAL_ADJACENT_TISSUE | None | Histologically normal tissue collected from a site adjacent to a tumor, used ... |
| NOT_ALLOWED_TO_COLLECT | None | A sample that was not obtained because collection was prohibited by consent, ... |
| NOT_REPORTED | None | The source material type was not documented or reported for this sample |
| PLEURAL_EFFUSION | None | Fluid collected from the pleural cavity, which may contain tumor cells in the... |
| POST_NEOADJUVANT_THERAPY | None | Tumor tissue collected after the administration of neoadjuvant (pre-surgical)... |
| PRIMARY_BLOOD_DERIVED_CANCER_BONE_MARROW | None | The initial cancerous bone marrow sample collected from a patient with a bloo... |
| PRIMARY_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD | None | The initial cancerous peripheral blood sample collected from a patient with a... |
| PRIMARY_TUMOR | None | Tissue collected from the original site of tumor origin, prior to any metasta... |
| PRIMARY_XENOGRAFT_TISSUE | None | Tumor tissue derived from a first-generation xenograft established directly f... |
| RECURRENT_BLOOD_DERIVED_CANCER_BONE_MARROW | None | Cancerous bone marrow sample collected at the time of disease recurrence in a... |
| RECURRENT_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD | None | Cancerous peripheral blood sample collected at the time of disease recurrence... |
| RECURRENT_TUMOR | None | Tumor tissue collected following disease recurrence after prior treatment or ... |
| RNA | None | Ribonucleic acid extracted from a biological sample for transcriptomic or gen... |
| SALIVA | None | Saliva collected as a non-invasive source of DNA or other biological material... |
| SLIDES | None | Prepared microscopy slides containing tissue or cell specimens for histologic... |
| SOLID_TISSUE_NORMAL | None | Non-cancerous solid tissue used as a normal reference for genomic or molecula... |
| TOTAL_RNA | None | The complete RNA complement extracted from a sample, including messenger, rib... |
| TUMOR | None | Tissue derived from a malignant neoplasm, used broadly when more specific tum... |
| TUMOR_ADJACENT_NORMAL_POST_NEOADJUVANT_THERAPY | None | Histologically normal tissue adjacent to a tumor, collected after completion ... |
| UNKNOWN | None | The source material type is not known or could not be determined for this sam... |
| XENOGRAFT_TISSUE | None | Tumor tissue derived from a xenograft model in which human tumor cells are pr... |
Slots
| Name | Description |
|---|---|
| source_material_type | The general kind of material from which the specimen was derived |
Identifier and Mapping Information
Schema Source
- from schema: https://w3id.org/bdchm
LinkML Source
name: SourceMaterialTypeEnum
from_schema: https://w3id.org/bdchm
rank: 1000
permissible_values:
ADDITIONAL_METASTATIC:
text: ADDITIONAL_METASTATIC
description: A metastatic tumor sample collected in addition to a previously collected
metastatic specimen.
ADDITIONAL_NEW_PRIMARY:
text: ADDITIONAL_NEW_PRIMARY
description: A new primary tumor sample collected in addition to a previously
collected primary specimen.
BENIGN_NEOPLASMS:
text: BENIGN_NEOPLASMS
description: Tissue derived from a non-cancerous tumor that does not invade nearby
tissue or metastasize.
BLOOD_DERIVED_CANCER_BONE_MARROW:
text: BLOOD_DERIVED_CANCER_BONE_MARROW
description: Cancerous cells isolated from bone marrow as part of a blood-derived
cancer sample.
BLOOD_DERIVED_CANCER_BONE_MARROW_POST_TREATMENT:
text: BLOOD_DERIVED_CANCER_BONE_MARROW_POST_TREATMENT
description: Cancerous cells isolated from bone marrow following therapeutic intervention.
BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD:
text: BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD
description: Cancerous cells isolated from peripheral blood as part of a blood-derived
cancer sample.
BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD_POST_TREATMENT:
text: BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD_POST_TREATMENT
description: Cancerous cells isolated from peripheral blood following therapeutic
intervention.
BLOOD_DERIVED_LIQUID_BIOPSY:
text: BLOOD_DERIVED_LIQUID_BIOPSY
description: Tumor-derived material, such as circulating tumor DNA or cells, extracted
from a blood sample.
BLOOD_DERIVED_NORMAL:
text: BLOOD_DERIVED_NORMAL
description: Non-cancerous blood sample used as a normal reference for genomic
or molecular analyses.
BONE_MARROW_NORMAL:
text: BONE_MARROW_NORMAL
description: Non-cancerous bone marrow sample used as a normal reference for genomic
or molecular analyses.
BUCCAL_CELL_NORMAL:
text: BUCCAL_CELL_NORMAL
description: Normal cells collected from the inner cheek mucosa, typically used
as a germline reference.
CELL_LINE_DERIVED_XENOGRAFT_TISSUE:
text: CELL_LINE_DERIVED_XENOGRAFT_TISSUE
description: Tumor tissue derived from a xenograft model that was originally established
from a cultured cell line.
CELL_LINES:
text: CELL_LINES
description: Immortalized cells grown in culture, derived from tumor or normal
tissue for experimental use.
CONTROL_ANALYTE:
text: CONTROL_ANALYTE
description: A reference material used to validate or calibrate laboratory assays
and analytical processes.
DNA:
text: DNA
description: Deoxyribonucleic acid extracted from a biological sample for genomic
analysis.
EBV_IMMORTALIZED_NORMAL:
text: EBV_IMMORTALIZED_NORMAL
description: Normal B-lymphocytes immortalized by Epstein-Barr virus transformation,
used as a germline reference.
EXPANDED_NEXT_GENERATION_CANCER_MODEL:
text: EXPANDED_NEXT_GENERATION_CANCER_MODEL
description: A cancer model, such as an organoid or cell line, that has been propagated
or expanded from a next-generation model system.
FFPE_RECURRENT:
text: FFPE_RECURRENT
description: Formalin-fixed paraffin-embedded tissue from a recurrent tumor, preserved
for histological or molecular analysis.
FFPE_SCROLLS:
text: FFPE_SCROLLS
description: Thin sections cut from formalin-fixed paraffin-embedded tissue blocks
for nucleic acid or protein extraction.
FIBROBLASTS_FROM_BONE_MARROW_NORMAL:
text: FIBROBLASTS_FROM_BONE_MARROW_NORMAL
description: Normal fibroblast cells isolated from bone marrow, used as a non-cancerous
reference.
GRANULOCYTES:
text: GRANULOCYTES
description: White blood cells of the granulocyte lineage isolated from blood,
often used as a normal germline reference.
HUMAN_TUMOR_ORIGINAL_CELLS:
text: HUMAN_TUMOR_ORIGINAL_CELLS
description: Primary tumor cells taken directly from a human subject without prior
in vitro expansion.
IN_SITU_NEOPLASMS:
text: IN_SITU_NEOPLASMS
description: Tissue from a neoplasm that has not yet invaded surrounding tissue,
representing an early-stage malignancy.
LYMPHOID_NORMAL:
text: LYMPHOID_NORMAL
description: Non-cancerous lymphoid tissue used as a normal reference for genomic
or molecular analyses.
METASTATIC:
text: METASTATIC
description: Tumor tissue collected from a site distant from the primary tumor,
representing metastatic disease.
MIXED_ADHERENT_SUSPENSION:
text: MIXED_ADHERENT_SUSPENSION
description: A cell culture sample containing both adherent and suspension cell
populations.
MONONUCLEAR_CELLS_FROM_BONE_MARROW_NORMAL:
text: MONONUCLEAR_CELLS_FROM_BONE_MARROW_NORMAL
description: Normal mononuclear cells isolated from bone marrow, used as a non-cancerous
reference.
NEOPLASMS_OF_UNCERTAIN_AND_UNKNOWN_BEHAVIOR:
text: NEOPLASMS_OF_UNCERTAIN_AND_UNKNOWN_BEHAVIOR
description: Tissue from a neoplasm whose malignant potential cannot be determined
based on available information.
NEXT_GENERATION_CANCER_MODEL:
text: NEXT_GENERATION_CANCER_MODEL
description: A modern in vitro or in vivo cancer model, such as a patient-derived
organoid or xenograft, that recapitulates tumor biology.
NORMAL_ADJACENT_TISSUE:
text: NORMAL_ADJACENT_TISSUE
description: Histologically normal tissue collected from a site adjacent to a
tumor, used as a local reference.
NOT_ALLOWED_TO_COLLECT:
text: NOT_ALLOWED_TO_COLLECT
description: A sample that was not obtained because collection was prohibited
by consent, regulation, or protocol.
NOT_REPORTED:
text: NOT_REPORTED
description: The source material type was not documented or reported for this
sample.
PLEURAL_EFFUSION:
text: PLEURAL_EFFUSION
description: Fluid collected from the pleural cavity, which may contain tumor
cells in the context of malignancy.
POST_NEOADJUVANT_THERAPY:
text: POST_NEOADJUVANT_THERAPY
description: Tumor tissue collected after the administration of neoadjuvant (pre-surgical)
therapy.
PRIMARY_BLOOD_DERIVED_CANCER_BONE_MARROW:
text: PRIMARY_BLOOD_DERIVED_CANCER_BONE_MARROW
description: The initial cancerous bone marrow sample collected from a patient
with a blood-derived malignancy.
PRIMARY_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD:
text: PRIMARY_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD
description: The initial cancerous peripheral blood sample collected from a patient
with a blood-derived malignancy.
PRIMARY_TUMOR:
text: PRIMARY_TUMOR
description: Tissue collected from the original site of tumor origin, prior to
any metastatic spread.
PRIMARY_XENOGRAFT_TISSUE:
text: PRIMARY_XENOGRAFT_TISSUE
description: Tumor tissue derived from a first-generation xenograft established
directly from a patient sample.
RECURRENT_BLOOD_DERIVED_CANCER_BONE_MARROW:
text: RECURRENT_BLOOD_DERIVED_CANCER_BONE_MARROW
description: Cancerous bone marrow sample collected at the time of disease recurrence
in a blood-derived malignancy.
RECURRENT_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD:
text: RECURRENT_BLOOD_DERIVED_CANCER_PERIPHERAL_BLOOD
description: Cancerous peripheral blood sample collected at the time of disease
recurrence in a blood-derived malignancy.
RECURRENT_TUMOR:
text: RECURRENT_TUMOR
description: Tumor tissue collected following disease recurrence after prior treatment
or remission.
RNA:
text: RNA
description: Ribonucleic acid extracted from a biological sample for transcriptomic
or gene expression analysis.
SALIVA:
text: SALIVA
description: Saliva collected as a non-invasive source of DNA or other biological
material, typically for germline analysis.
SLIDES:
text: SLIDES
description: Prepared microscopy slides containing tissue or cell specimens for
histological or molecular examination.
SOLID_TISSUE_NORMAL:
text: SOLID_TISSUE_NORMAL
description: Non-cancerous solid tissue used as a normal reference for genomic
or molecular analyses.
TOTAL_RNA:
text: TOTAL_RNA
description: The complete RNA complement extracted from a sample, including messenger,
ribosomal, and non-coding RNA species.
TUMOR:
text: TUMOR
description: Tissue derived from a malignant neoplasm, used broadly when more
specific tumor classification is not specified.
TUMOR_ADJACENT_NORMAL_POST_NEOADJUVANT_THERAPY:
text: TUMOR_ADJACENT_NORMAL_POST_NEOADJUVANT_THERAPY
description: Histologically normal tissue adjacent to a tumor, collected after
completion of neoadjuvant therapy.
UNKNOWN:
text: UNKNOWN
description: The source material type is not known or could not be determined
for this sample.
XENOGRAFT_TISSUE:
text: XENOGRAFT_TISSUE
description: Tumor tissue derived from a xenograft model in which human tumor
cells are propagated in an animal host.